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Coliprim

Coliprim

Liquid

Composition:

Composition:
Each 1ml contains:
Trimethoprim 40 mg
Sulphadiazine Sodium 200 mg

Properties:

COLIPRIM liquid is an oral solution composed of trimethoprim and Sulphadiazine.

The action of the combination was proved to be bactericidal where as the component separately only bacteriostatic as trimethoprim potentates the antibacterial activity of Sulphadiazine against a wide range of Gram-positive and Gram-negative bacteria.
Sulphonamides act as an analogue for para-aminobenzoic acid, (PABA) which itself a part of the vitamin, folic acid.

In organisms that synthesis their own folic acid, sulphonamides as sulphadiazine acts by blocking the synthesis of folic acid.

Sulphonamides are active against bacteria but not against higher organisms as bacteria synthetic their own folic acid whereas higher animals or higher organisms obtained folic acid from the diet.